Human Oncoviruses: A Journey from Epstein Barr virus (EBV) to Acquired Immunodeficiency Syndrome (AIDS) through Cancer
DOI:
https://doi.org/10.63419/sayam.v2i1.57Keywords:
Epstein Barr virus (EBV), Acquired Immunodeficiency Syndrome (AIDS), Human oncovirus, Pathogenesis, CancerAbstract
A major breakthrough in oncology and a major contribution to our understanding of human oncoviruses has been made with the discovery of the Epstein Barr virus (EBV), the first virus known to cause cancer. This trip has shown a complex link between viral infections and oncogenesis, spanning from EBV to the complexity of Acquired Immunodeficiency Syndrome (AIDS). Since EBV has been linked to Burkitt's lymphoma, researchers have been investigating the viral processes behind cellular transformation. The Human T-cell Leukaemia Virus (HTLV-1) and Human Papillomavirus (HPV) have yielded additional discoveries that have broadened our understanding of immune evasion, viral oncogenes, and the role chronic inflammation plays in vehicle development. A paradigm shift emphasizing the interaction between immunodeficiency and cancer was brought about by the emergence of AIDS.
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